proteomics paves the way for q fever diagnostics蛋白质组学为q热诊断铺平了道路.pdfVIP

Kowalczewska et al. Genome Medicine 2011, 3:50 /content/3/7/50 R E V I E W Proteomics paves the way for Q fever diagnostics 1 2 1 Malgorzata Kowalczewska *, Zuzana Sekeyová and Didier Raoult Presentation of the disease is extremely variable. A non- Abstract immunized person develops a primary infection in 60% Q fever is a worldwide zoonosis caused by Coxiella of cases (Table 1). is can lead to the acute disease (in burnetii. The disease most frequently manifests clinically 40% of cases), which mostly presents as a flu-like syn- as a self-limited febrile illness, as pneumonia (acute drome or as severe pneumonia; 2% of patients with acute Q fever) or as a chronic illness that presents mainly as disease are hospitalized [1]. In patients with pre-existing infective endocarditis. The extreme infectivity of the valvulopathy, infection can progress to the chronic form bacterium results in large outbreaks, and the recent (in 2-5% of patients), which is characterized by blood- outbreak in the Netherlands underlines its impact culture-negative endocarditis [1,4]. e fever and charac- on public health. Recent studies on the bacterium teristic vegetations (a mixture of bacteria and blood clots have included genome sequencing, the investigation on heart valves) are frequently absent, making diagnosis of host-bacterium interactions, the development difficult [1]. Importantly, Q fever is associated with high of cellular and animal models of infection, and the