raised intrathecal levels of april and baff in patients with systemic lupus erythematosus relationship to neuropsychiatric symptoms鞘内水平的4月和高飞球的一击在系统性红斑狼疮患者神经精神症状的关系.pdfVIP

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raised intrathecal levels of april and baff in patients with systemic lupus erythematosus relationship to neuropsychiatric symptoms鞘内水平的4月和高飞球的一击在系统性红斑狼疮患者神经精神症状的关系.pdf

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raised intrathecal levels of april and baff in patients with systemic lupus erythematosus relationship to neuropsychiatric symptoms鞘内水平的4月和高飞球的一击在系统性红斑狼疮患者神经精神症状的关系

Available online /content/10/4/R97 Vol 10 No 4 Open Access Research article Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus: relationship to neuropsychiatric symptoms 1,2 3 1 Annie George-Chandy , Estelle Trysberg and Kristina Eriksson 1Department of Rheumatology and Inflammation Research, Guldhedsgatan 10A, 413 46 Gothenburg, Sweden 2Department of Infection Immunology, Statens Serum Institut, Artillerivej 5, 232 300 Copenhagen, Denmark 3Rheumatogy Unit at Karolinska University Hospital/Huddinge, Hälsovägen 141, 141 52 Huddinge, Sweden Corresponding author: Annie George-Chandy, annie.george.chandy@microbio.gu.se Received: 2 Apr 2008 Revisions requested: 29 Apr 2008 Revisions received: 28 Jul 2008 Accepted: 22 Aug 2008 Published: 22 Aug 2008 Arthritis Research Therapy 2008, 10:R97 (doi:10.1186/ar2484) This article is online at: /content/10/4/R97 © 2008 George-Chandy et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The tumour necrosis factor (TNF) family ligands Separate analyses of SLE patients with and without CNS BAFF (B-cell activating factor of TNF family) and APRIL (a involvement revealed that NPSLE patients had enhanced levels proliferation-inducing ligand) are essential for B-cell survival and of APRIL in CSF. BAFF and APRIL were likely p