原创力文档repercussions of mild diabetes on pregnancy in wistar rats and on the fetal development轻度糖尿病对妊娠的影响wistar鼠和胎儿发育.pdfVIP
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repercussions of mild diabetes on pregnancy in wistar rats and on the fetal development轻度糖尿病对妊娠的影响wistar鼠和胎儿发育
Saito et al. Diabetology Metabolic Syndrome 2010, 2:26
/content/2/1/26
R E S E A R C H Open Access
Research
Repercussions of mild diabetes on pregnancy in
Wistar rats and on the fetal development
1 1 2 1 1 1,3
Felipe H Saito , Débora C Damasceno* , Wilma G Kempinas , Glilciane Morceli , Yuri K Sinzato , Kristin N Taylor and
Marilza VC Rudge1
Abstract
Background: Experimental models are necessary to elucidate diabetes pathophysiological mechanisms not yet
understood in humans. Objective: To evaluate the repercussions of the mild diabetes, considering two methodologies,
on the pregnancy of Wistar rats and on the development of their offspring.
Methods: In the 1st induction, female offspring were distributed into two experimental groups: Group streptozotocin
(STZ, n = 67): received the β-cytotoxic agent (100 mg STZ/kg body weight - sc) on the 1st day of the life; and Non-
diabetic Group (ND, n = 14): received the vehicle in a similar time period. In the adult life, the animals were mated. After
a positive diagnosis of pregnancy (0), female rats from group STZ presenting with lower glycemia than 120 mg/dL
received more 20 mg STZ/kg (ip) at day 7 of pregnancy (2nd induction). The female rats with glycemia higher than 120
mg/dL were discarded because they reproduced results already found in the literature. In the mornings of days 0, 7, 14
and 21 of the pregnancy glycemia was determined. At day 21 of pregnancy (at term), the female rats were anesthetized
and killed for maternal reproductive performance and fetal development analysis. The data were analyzed using
Student-Newman-Keuls, Chi-square and Zero-inflated Poisson (ZIP) Tests (p 0.05).
Results: ST
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