原创力文档reinforcing effects of methamphetamine in an animal model of attention-deficithyperactivity disorder-the spontaneously hypertensive rat加强甲基苯丙胺的动物模型的影响attention-deficithyperactivity引起自发性高血压鼠.pdfVIP
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reinforcing effects of methamphetamine in an animal model of attention-deficithyperactivity disorder-the spontaneously hypertensive rat加强甲基苯丙胺的动物模型的影响attention-deficithyperactivity引起自发性高血压鼠
dela Peña et al. Behavioral and Brain Functions 2010, 6:72
/content/6/1/72
SHORT PAPER Open Access
Reinforcing effects of methamphetamine in an
animal model of Attention-Deficit/Hyperactivity
Disorder-the Spontaneously Hypertensive Rat
1 1 1 2 3 1*
Ike dela Peña , Hyung Seok Ahn , Ji Young Choi , Chan Young Shin , Jong Hoon Ryu , Jae Hoon Cheong
Abstract
Substrains of the Spontaneously Hypertensive rat (SHR), a putative animal model of Attention-Deficit/Hyperactivity
Disorder (ADHD), have demonstrated increased sensitivity to many drugs of abuse, including psychostimulants.
Therefore, it was suggested that studies in SHR may help elucidate ADHD and comorbidity with substance use dis-
order (SUD). However, the drug intake profile of the SHR in the most relevant animal model of drug addiction, the
self-administration (SA) test, and its response on the conditioned place preference (CPP) paradigm are not yet
determined. In the present study, we employed SA and CPP tests to investigate the reinforcing effects of the psy-
chostimulant methamphetamine in an SHR substrain obtained from Charles River, Japan (SHR/NCrlCrlj). Concurrent
tests were also performed in Wistar rats, the strain representing “normal” heterogeneous population. To address if
the presence of ADHD behaviors further increases sensitivity to the rewarding effect of methamphetamine during
adolescence, a critical period for the onset of drug abuse, CPP tests were especially conducted in adolescent Wistar
and SHR/NCrlCrlj. We found that the SHR/NCrlCrlj also acquired methamphetamine SA and CPP, indicating reinfor-
cing effects of methamphetamine in this ADHD animal model. However, we did not observe increased responsive-
ness of the SHR/NCr
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