原创力文档recombinant human activated protein c current insights into its mechanism of action重组人蛋白c激活当前洞察的作用机制.pdfVIP
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recombinant human activated protein c current insights into its mechanism of action重组人蛋白c激活当前洞察的作用机制
Available online /content/11/S5/S3
Review
Recombinant human activated protein C: current insights into its
mechanism of action
Marcel Levi1 and Tom van der Poll1-3
1Department of Medicine, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands
2Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands
3Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands
Corresponding author: Marcel Levi, m.m.levi@amc.uva.nl
Published: 19 December 2007 Critical Care 2007, 11(Suppl 5):S3 (doi:10.1186/cc6154)
This article is online at /content/11/S5/S3
© 2007 BioMed Central Ltd
Abstract Activated protein C (APC) appears to play a central role in
Impairment of the protein C pathway plays a central role in the the pathogenesis of sepsis and associated organ dys-
pathogenesis of sepsis. Administration of recombinant human function. There is ample evidence that insufficient functioning
activated protein C (rhAPC) may correct the dysregulated anti- of the protein C pathway contributes to the derangement of
coagulant mechanism and prevent propagation of thrombin coagulation observed in sepsis [5,6]. The protein C system is
generation and formation of microvascular thrombosis. Further- summarized in Figure 1. The circulating zymogen protein C is
more, it may simultaneously modulate the inflammatory response. It
activated by the endothelial cell bound thrombomodulin once
is likely that the benefi
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