recombinant erythropoietin for the anaemia of patients with advanced gastrointestinal stromal tumours (gist) receiving imatinib an active agent only in non progressive patients重组红细胞生成素晚期胃肠道间质肿瘤患者的贫血(要点)接受伊马替尼活性剂只在非渐进的病人.pdfVIP
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recombinant erythropoietin for the anaemia of patients with advanced gastrointestinal stromal tumours (gist) receiving imatinib an active agent only in non progressive patients重组红细胞生成素晚期胃肠道间质肿瘤患者的贫血(要点)接受伊马替尼活性剂只在非渐进的病人
CLINICAL SARCOMA RESEARCH
Recombinant erythropoietin for the anaemia of
patients with advanced Gastrointestinal Stromal
Tumours (GIST) receiving imatinib: an active
agent only in non progressive patients
Duffaud et al.
Duffaud et al. Clinical Sarcoma Research 2012, 2:11
/content/2/1/11
Duffaud et al. Clinical Sarcoma Research 2012, 2:11
/content/2/1/11 CLINICAL SARCOMA RESEARCH
RESEARCH Open Access
Recombinant erythropoietin for the anaemia of
patients with advanced Gastrointestinal Stromal
Tumours (GIST) receiving imatinib: an active
agent only in non progressive patients
1 2 4 3 1
Florence Duffaud , Caroline Even , Isabelle Ray-Coquard , Emmanuelle Bompas , Thanh Khoa-Huynh ,
1 4 4 2 4
Sebastien Salas , Philippe Cassier , Armelle Dufresne , Sylvie Bonvalot , Francoise Ducimetiere ,
Axel Le Cesne2 and Jean-Yves Blay4*
Abstract: Recombinant erythropoietin for the anaemia of patients with advanced Gastrointestinal Stromal Tumours
(GIST) receiving imatinib : an active agent only in non progressive patients.
Background: Imatinib is a standard treatment for advanced/metastatic GIST and in adjuvant setting. Anaemia is
frequently observed in patients with advanced GIST, and is one of the most frequent side effects of imatinib with
grade 3–4 anaemia in 10% of patients. Whether EPO treatment is useful in the management of GIST patients
receiving imatinib treatment is unknown.
Methods: A retrospective study of EPO treatment in
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