recombinant human activated protein c attenuates endotoxin-induced lung injury in awake sheep重组人蛋白c激活减弱endotoxin-induced清醒绵羊肺损伤.pdfVIP

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recombinant human activated protein c attenuates endotoxin-induced lung injury in awake sheep重组人蛋白c激活减弱endotoxin-induced清醒绵羊肺损伤.pdf

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recombinant human activated protein c attenuates endotoxin-induced lung injury in awake sheep重组人蛋白c激活减弱endotoxin-induced清醒绵羊肺损伤

Available online /content/12/4/R104 Vol 12 No 4 Open Access Research Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep 1 1 1,2 3 4 Kristine Waerhaug , Vladimir N Kuklin , Mikhail Y Kirov , Mikhail A Sovershaev , Bodil Langbakk , 5 6 1 Ole C Ingebretsen , Kirsti Ytrehus and Lars J Bjertnaes 1Department of Anesthesiology, Institute of Clinical Medicine, Faculty of Medicine, University of Tromsø, Norway 2Department of Anesthesiology, Northern State Medical University, Arkhangelsk, Russian Federation 3Department of Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway 4Department of Medical Biochemistry, University Hospital of North Norway, Tromsø, Norway 5Department of Medical Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway 6Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway Corresponding author: Lars J Bjertnaes, lars.bjertnaes@fagmed.uit.no Received: 19 Jun 2008 Revisions requested: 19 Jul 2008 Revisions received: 1 Aug 2008 Accepted: 15 Aug 2008 Published: 15 Aug 2008 Critical Care 2008, 12:R104 (doi:10.1186/cc6985) This article is online at: /content/12/4/R104 © 2008 Waerhaug et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits u