resistance to il-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in cd4+ t cells from patients with rheumatoid arthritis抗il - 10的抑制干扰素γ生产和抑制细胞因子信号1的表达cd4 + t细胞在类风湿性关节炎患者.pdfVIP

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resistance to il-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in cd4+ t cells from patients with rheumatoid arthritis抗il - 10的抑制干扰素γ生产和抑制细胞因子信号1的表达cd4 + t细胞在类风湿性关节炎患者.pdf

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resistancetoil-10inhibitionofinterferongammaproductionandexpressionofsuppressorofcytokinesignaling1incd4tcellsfrompatientswithrheumatoidarthritis抗il-10的抑制干扰素γ生产和抑制细胞因子信号1的表达cd4t细胞在类风湿性关节炎患者

Available online /content/6/6/R567 Vol 6 No 6 Open Access Research article Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritis Jiro Yamana, Masahiro Yamamura, Akira Okamoto, Tetsushi Aita, Mitsuhiro Iwahashi, Katsue Sunahori and Hirofumi Makino Department of Medicine and Clinical Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan Corresponding author: Masahiro Yamamura, yamamura@md.okayama-u.ac.jp Received: 26 May 2004 Revisions requested: 1 Jul 2004 Revisions received: 20 Jul 2004 Accepted: 25 Aug 2004 Published: 13 Oct 2004 Arthritis Res Ther 2004, 6:R567-R577 (DOI 10.1186/ar1445) /content/6/6/R567 © 2004 Yamana et al., licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited. Abstract IL-10 has been shown to block the antigen-specific T-cell abolished by neutralizing anti-IL-6 antibody. Preincubation of cytokine response by inhibiting the CD28 signaling pathway. normal CD4+ T cells with IL-6 reduced IL-10-mediated inhibition We found that peripheral blood CD4+ T cells from patients with of interferon gamma production. Blood CD4+ T cells from RA active rheumatoid arthritis (RA) were able to produce greater patients contained higher levels of suppressor of cytokine