respective prognostic value of genomic grade and histological proliferation markers in early stage (pn0) breast carcinoma各自的基因组品位和组织学的预后价值增殖标记早期乳腺癌(pn0).pdfVIP

Respective Prognostic Value of Genomic Grade and Histological Proliferation Markers in Early Stage (pN0) Breast Carcinoma 1,7 2 3 4 5 ´ ` Fabien Reyal , Marc A. Bollet , Martial Caly , David Gentien , Sabrina Carpentier , Helene Peyro-Saint- 5 6 6 ´ 6 3 Paul , Jean-Yves Pierga , Paul Cottu , Veronique Dieras , Brigitte Sigal-Zafrani , Anne Vincent- 3 3 Salomon , Xavier Sastre-Garau * ´ ´ ´ ´ 1 Departement de chirurgie, Institut Curie, Paris, France, 2 Departement de radiotherapie, Institut Curie, Paris, France, 3 Departement de biologie des tumeurs, Institut ´ ´ ´ Curie, Paris, France, 4 Departement de transfert, Institut Curie, Paris, France, 5 Ipsogen SA, Marseille, France, 6 Departement d’oncologie medicale, Institut Curie, Paris, ´ France, 7 UMR144, CNRS, Institut Curie, Equipe Oncologie Moleculaire, Paris, France Abstract Background: Genomic grade (GG) is a 97-gene signature which improves the accuracy and prognostic value of histological grade (HG) in invasive breast carcinoma. Since most of the genes included in the GG are involved in cell proliferation, we performed a retrospective study to compare the prognostic value of GG, Mitotic Index and Ki67 score. Methods: A series of 163 consecutive breast cancers was retained (pT1–2, pN0, pM0, 10-yr follow-up). GG was computed using MapQu