原创力文档resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity白藜芦醇抑制体重增加肥胖的季节性非人灵长类动物模型.pdfVIP
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resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity白藜芦醇抑制体重增加肥胖的季节性非人灵长类动物模型
Dal-Pan et al. BMC Physiology 2010, 10:11
/1472-6793/10/11
R E S E A R C H A R T I C L E Open Access
Research article
Resveratrol suppresses body mass gain in a
seasonal non-human primate model of obesity
1 2 1
Alexandre Dal-Pan , Stéphane Blanc and Fabienne Aujard*
Abstract
Background: Resveratrol, a natural polyphenolic compound, was shown to protect rodents against high-fat-diet
induced diabesity by boosting energy metabolism. To the best of our knowledge, no data is yet available on the effects
of resveratrol in non-human primates. Six non-human heterotherm primates (grey mouse lemurs, Microcebus murinus)
were studied during four weeks of dietary supplementation with resveratrol (200 mg/kg/day) during their winter body-
mass gain period. Body mass, spontaneous energy intake, resting metabolic rate, spontaneous locomotor activity and
daily variations in body temperature were measured. In addition, the plasma levels of several gut hormones involved in
satiety control were evaluated.
Results: Resveratrol reduced the seasonal body-mass gain by concomitantly decreasing energy intake by 13% and
increasing resting metabolic rate by 29%. Resveratrol supplementation inhibited the depth of daily torpor, an
important energy-saving process in this primate. The daily amount of locomotor activity remained unchanged. Except
for an increase in the glucose-dependent insulinotropic polypeptide, a gut hormone known to promote mobilization
of fat stores, no major change in satiety hormone plasma levels was observed under resveratrol supplementation.
Conclusions: These results suggest that in a non-human primate, resveratrol reduces body-mass gain by increasing
satiety and resting metabolic rate, and by inhibiting torpor expression. The measured anorectic gut hormo
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