reversible disruption of pre-pulse inhibition in hypomorphic-inducible and reversible cb1-- mice可逆中断hypomorphic-inducible pre-pulse抑制和可逆cb1u2014u2014老鼠.pdfVIP

Reversible Disruption of Pre-Pulse Inhibition in Hypomorphic-Inducible and Reversible CB1-/- Mice 1 1 1 1 Maria Franca Marongiu , Daniela Poddie , Susanna Porcu , Maria Francesca Manchinu , Maria 2,3 2 2 2 2 2,3 . Paola Castelli , Valeria Sogos , Valentina Bini , Roberto Frau , Elisabetta Caredda , Maria Collu * , 1 . Maria Serafina Ristaldi * 1 Institute of Genetic and Biomedical Research, National Research Council (IRGB-CNR), Monserrato, Italy, 2 Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy, 3 Center of Excellence for Neurobiology of Drug Dependence, University of Cagliari, Monserrato, Italy Abstract Although several genes are implicated in the pathogenesis of schizophrenia, in animal models for such a severe mental illness only some aspects of the pathology can be represented (endophenotypes). Genetically modified mice are currently being used to obtain or characterize such endophenotypes. Since its cloning and characterization CB1 receptor has increasingly become of significant physiological, pharmacological and clinical interest. Recently, its involvement in schizophrenia has been reported. Among the different approaches employed, gene targeting permits to study the multiple roles of the endocannabinoid system using knockout (-/-) mice represent a powerful model but with some limitations due to compensation. To overcome such a limitation, we have generated an indu