原创力文档rna sensors enable human mast cell anti-viral chemokine production and ifn-mediated protection in response to antibody-enhanced dengue virus infection核糖核酸传感器使人类肥大细胞抗病毒趋化因子在应对生产和ifn-mediated保护antibody-enhanced登革热病毒感染.pdfVIP
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rna sensors enable human mast cell anti-viral chemokine production and ifn-mediated protection in response to antibody-enhanced dengue virus infection核糖核酸传感器使人类肥大细胞抗病毒趋化因子在应对生产和ifn-mediated保护antibody-enhanced登革热病毒感染
RNA Sensors Enable Human Mast Cell Anti-Viral
Chemokine Production and IFN-Mediated Protection in
Response to Antibody-Enhanced Dengue Virus Infection
1,4. 1. 1,4 1 1,4
Michael G. Brown , Sarah M. McAlpine , Yan Y. Huang , Ian D. Haidl , Ayham Al-Afif ,
1,2 1,3,4
Jean S. Marshall , Robert Anderson *
1 Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada, 2 Department of Pathology, Dalhousie University, Halifax, Nova Scotia,
Canada, 3 Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada, 4 Canadian Center for Vaccinology, IWK Health Centre, Halifax, Nova Scotia,
Canada
Abstract
Dengue hemorrhagic fever and/or dengue shock syndrome represent the most serious pathophysiological manifestations
of human dengue virus infection. Despite intensive research, the mechanisms and important cellular players that contribute
to dengue disease are unclear. Mast cells are tissue-resident innate immune cells that play a sentinel cell role in host
protection against infectious agents via pathogen-recognition receptors by producing potent mediators that modulate
inflammation, cell recruitment and normal vascular homeostasis. Most importantly, mast cells are susceptible to antibody-
enhanced dengue virus infection and respond with selective cytokine and chemokine responses. In order to obtain a global
view of dengue virus-induced gene regulation in mast cells, primary human cord blood-derived mast cells (CBMCs) and the
KU812 and HMC-1 mast cell lines were infected with dengue virus in the presence of dengue-immune sera and
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