rotavirus stimulates release of serotonin (5-ht) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting轮状病毒刺激释放5 -羟色胺(5 -)从人类肠嗜铬细胞的细胞,激活大脑结构参与恶心和呕吐.pdfVIP

Rotavirus Stimulates Release of Serotonin (5-HT) from Human Enterochromaffin Cells and Activates Brain Structures Involved in Nausea and Vomiting Marie Hagbom1., Claudia Istrate 1,2¤a. , David Engblom3, Thommie Karlsson4, Jesus Rodriguez-Diaz5¤b, 5 6 4 4 ˚ 7 Javier Buesa , John A. Taylor , Vesa-Matti Loitto , Karl-Eric Magnusson , Hakan Ahlman , Ove Lundgren8, Lennart Svensson 1* ¨ ¨ 1 Division of Molecular Virology, Medical Faculty, University of Linkoping, Linkoping, Sweden, 2 Unidade de Biologia Molecular, Centro de Malaria e Outras Doenc¸as ¨ Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal, 3 Division of Cell Biology, Medical Faculty, University of Linkoping, ¨ ¨ ¨ Linkoping, Sweden, 4 Division of Medical Microbiology, Medical Faculty, University of Linkoping, Linkoping, Sweden, 5 Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain, 6 School of Biological Sciences, University of Auckland, Auckland, New Zealand, 7 Department of Surgery, University of Gothenburg, Gothenburg, Sweden, 8 Department of Physiology, University of Gothenburg, Gothenburg, Sweden Abstract Rotavirus (RV) is the major cause of severe gastroenteritis in young children. A virus-encoded enterotoxin, NSP4 is proposed to play a major role in causing