risk assessment, disease prevention and personalised treatments in breast cancer is clinically qualified integrative approach in the horizon风险评估、疾病预防和个体化治疗在乳腺癌临床资格综合疗法在地平线上.pdfVIP
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risk assessment, disease prevention and personalised treatments in breast cancer is clinically qualified integrative approach in the horizon风险评估、疾病预防和个体化治疗在乳腺癌临床资格综合疗法在地平线上
Golubnitschaja et al. The EPMA Journal 2013, 4:6
/content/4/1/6
REVIEW Open Access
Risk assessment, disease prevention and
personalised treatments in breast cancer: is
clinically qualified integrative approach in the
horizon?
1,2* 1,2 3 1,2 2,4,5
Olga Golubnitschaja , Kristina Yeghiazaryan , Vincenzo Costigliola , Daniela Trog , Michael Braun ,
Manuel Debald2,4, Walther Kuhn2,4 and Hans H Schild1,2
Abstract
Breast cancer is a multifactorial disease. A spectrum of internal and external factors contributes to the disease
promotion such as a genetic predisposition, chronic inflammatory processes, exposure to toxic compounds,
abundant stress factors, a shift-worker job, etc. The cumulative effects lead to high incidence of breast cancer in
populations worldwide. Breast cancer in the USA is currently registered with the highest incidence rates amongst
all cancer related patient cohorts. Currently applied diagnostic approaches are frequently unable to recognise early
stages in tumour development that impairs individual outcomes. Early diagnosis has been demonstrated to be
highly beneficial for significantly enhanced therapy efficacy and possibly full recovery. Actual paper shows that the
elaboration of an integrative diagnostic approach combining several levels of examinations creates a robust
platform for the reliable risk assessment, targeted preventive measures and more effective treatments tailored to
the person in the overall task of breast cancer management. The levels of examinations are proposed, and
innovative technological approaches are described in the paper. The absolute necessity to create individual patient
profiles and extended medical records is justified for t
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