resting-state brain organization revealed by functional covariance networks静息状态的大脑组织了协方差函数网络.pdfVIP

Resting-State Brain Organization Revealed by Functional Covariance Networks 1. 2. 3,4. 1 1 1 Zhiqiang Zhang , Wei Liao , Xi-Nian Zuo , Zhengge Wang , Cuiping Yuan , Qing Jiao , Huafu 2 5 1 6 Chen , Bharat B. Biswal , Guangming Lu *, Yijun Liu 1 Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China, 2 Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China, 3 Laboratory for Functional Connectome and Development, Institute of Psychology, Chinese Academy of Sciences. Beijing, China, 4 Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, New York University Child Study Center, New York, New York, United States of America, 5 Department of Radiology, UMDNJ New Jersey Medical School, Newark, New Jersey, United States of America, 6 Department of Psychiatry, University of Florida, Gainesville, Florida, United States of America Abstract Background: Brain network studies using techniques of intrinsic connectivity network based on fMRI time series (TS-ICN) and structural covariance network (SCN) have mapped out functional and structural organization of human brain at respective time scales. However, there lacks a meso-time-scale network to bridge the ICN and SCN and get insights of brain functional organization. Methodology and Principal Findings: We proposed a functional covariance network (FCN) method by measuring the covariance of amplitude of low-frequency fluctuations (ALFF) in BOLD signals across subjects, and compared the pattern