原创力文档restoration of electric footshock-induced immunosuppression in mice by gynostemma pentaphyllum components恢复电力footshock-induced免疫抑制小鼠的绞股蓝组件.pdfVIP
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restoration of electric footshock-induced immunosuppression in mice by gynostemma pentaphyllum components恢复电力footshock-induced免疫抑制小鼠的绞股蓝组件
Molecules 2012, 17, 7695-7708; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Restoration of Electric Footshock-Induced Immunosuppression
in Mice by Gynostemma pentaphyllum Components
Sun-A Im, Hyun Sook Choi, Soon Ok Choi, Ki-Hyang Kim, Seungjeong Lee, Bang Yeon Hwang,
Myung Koo Lee and Chong Kil Lee *
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea;
E-Mails: sunaim@chungbuk.ac.kr (S.-A.I.); 6151494@ (H.S.C.);
pa960001@cnuh.co.kr (S.O.C.); yes3343@ (K.-H.K.); chdang@ (S.L.);
byhwang@chungbuk.ac.kr (B.Y.H.); myklee@chungbuk.ac.kr (M.K.L.)
* Author to whom correspondence should be addressed; E-Mail: cklee@chungbuk.ac.kr;
Tel.: +82-43-261-2826; Fax: +82-43-261-3571.
Received: 17 February 2012; in revised form: 11 June 2012 / Accepted: 20 June 2012 /
Published: 25 June 2012
Abstract: The immunomodulatory effects of the ethanol extract of Gynostemma
pentaphyllum (GP-EX) were examined in electric footshock (EFS)-stressed mice. The mice
were orally administered various doses of GP-EX for 7 days before exposure to EFS
(duration: 3 min, interval: 10 s, intensity: 2 mA) once a day from day 8 for 14 days with
continuous daily feeding of GP-EX. Oral administration of GP-EX to mice prevented EFS
stress-induced immunosuppression as determined by the lymphoid organ (thymus and spleen)
weight and cellularity. In addition, oral administration of GP-EX restored EFS-suppressed
functional properties of mature lymphocytes in terms of c
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