resting state functional connectivity in perfusion imaging correlation maps with bold connectivity and resting state perfusion静息状态的功能连通性灌注成像相关地图与大胆的连通性和静止状态灌注.pdfVIP

Resting State Functional Connectivity in Perfusion Imaging: Correlation Maps with BOLD Connectivity and Resting State Perfusion 1 1,2 3 Roberto Viviani *, Irene Messina , Martin Walter 1 Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany, 2 Department of Applied Psychology, University of Padua, Padua, Italy, 3 Clinical Affective Neuroimaging Laboratory, Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany Abstract Functional connectivity is a property of the resting state that may provide biomarkers of brain function and individual differences. Classically, connectivity is estimated as the temporal correlation of spontaneous fluctuations of BOLD signal. We investigated differences in connectivity estimated from the BOLD and CBF signal present in volumes acquired with arterial spin labeling technique in a large sample (N = 265) of healthy individuals. Positive connectivity was observable in both BOLD and CBF signal, and was present in the CBF signal also at frequencies lower than 0.009 Hz, here investigated for the first time. Negative connectivity was more variable. The validity of positive connectivity was confirmed by the existence of correlation across individuals in its intensity estimated from the BOLD and CBF signal. In contrast, there was little or no correlation across individuals between intensity of connectivity and mean perfusion levels, suggesting that these two biomarkers correspond to distinct sources of individual differences. Citation: Viviani R, Messina I, Walter M (2011) Resting State Functional Connectivity in Perfusion Imaging: Correlation Maps with BOLD Connectivity and Resting State Perfusion. PLoS ONE 6(11): e27050. doi:10.1371/journal.pone.0027050 Editor: Xi-Nian Zuo, In