restraint of appetite and reduced regional brain volumes in anorexia nervosa a voxel-based morphometric study抑制食欲,减少区域脑容量厌食症分布的形态学研究.pdfVIP

Brooks et al. BMC Psychiatry 2011, 11:179 /1471-244X/11/179 RESEARCH ARTICLE Open Access Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study 1,3* 2 2 2 2 Samantha J Brooks , Gareth J Barker , Owen G O’Daly , Michael Brammer , Steven CR Williams , 3 3 1 1 Christian Benedict , Helgi B Schiöth , Janet Treasure and Iain C Campbell Abstract Background: Previous Magnetic Resonance Imaging (MRI) studies of people with anorexia nervosa (AN) have shown differences in brain structure. This study aimed to provide preliminary extensions of this data by examining how different levels of appetitive restraint impact on brain volume. Methods: Voxel based morphometry (VBM), corrected for total intracranial volume, age, BMI, years of education in 14 women with AN (8 RAN and 6 BPAN) and 21 women (HC) was performed. Correlations between brain volume and dietary restraint were done using Statistical Package for the Social Sciences (SPSS). Results: Increased right dorsolateral prefrontal cortex (DLPFC) and reduced right anterior insular cortex, bilateral parahippocampal gyrus, left fusiform gyrus, left cerebellum and right posterior cingulate volumes in AN compared to HC. RAN compared to BPAN had reduced left orbitofrontal cortex, right anterior insular cortex, bilateral parahippocampal gyrus and left cerebellum. Age negatively correlated with right DLPFC volume in HC but not in AN; dietary restraint and BMI predicted 57% of variance in right DLPFC volume in AN. Conclusions: In AN, brain volume differences were found in appetitive, somatosensory and top-down control br