renal dysfunction in chronic liver disease在慢性肝病肾功能障碍.pdfVIP

Slack et al. Critical Care 2010, 14:214 /content/14/2/214 R E V I E W Renal dysfunction in chronic liver disease Andy Slack, Andrew Yeoman, and Julia Wendon* This article is one of ten reviews selected from the Yearbook of Intensive Care and Emergency Medicine 2010 (Springer Verlag) and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum/series/yearbook. Further information about the Yearbook of Intensive Care and Emergency Medicine is available from /series/2855. Introduction increasing incidence of obesity in the Western population Acute kidney injury (AKI), chronic kidney disease, and and the associated metabolic syndrome, consisting of the evaluation of numerous exogenous and endogenous atherosclerotic coronary vascular disease, hypertension, measures of kidney function and injury continue to be hyperlipidemia, diabetes, and chronic kidney disease. the focus of much research in diff erent patient Metabolic syndrome and non-alcoholic steato-hepatitis/ populations. h e key reason behind this eff ort is the well non-alcoholic fatty liver disease are linked by the key described independent association that small changes in feature of insulin resistance. Although initially considered kidney function are strongly linked with increased to be a benign disease, non-alcoholic fatty liver disease mortality, extending to those with chronic liver disease. seems to represent a spectrum of disease with benign h e accurate assessment of kidney function and injury hepatic steatosis at one end