原创力文档restored circulating invariant nkt cells are associated with viral control in patients with chronic hepatitis b恢复循环不变式nkt细胞与病毒控制在慢性乙型肝炎患者.pdfVIP
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restored circulating invariant nkt cells are associated with viral control in patients with chronic hepatitis b恢复循环不变式nkt细胞与病毒控制在慢性乙型肝炎患者
Restored Circulating Invariant NKT Cells Are Associated
with Viral Control in Patients with Chronic Hepatitis B
1,2 1 1 1 1 1
Xiaotao Jiang , Mingxia Zhang , Qintao Lai , Xuan Huang , Yongyin Li , Jian Sun , William G.H.
1,3 1 1
Abbott , Shiwu Ma , Jinlin Hou *
1 Institute of Hepatology and Key Lab for Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China,
2 Department of Immunology, Basic Medicine School, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China, 3 The New Zealand Liver
Transplant Unit, Auckland City Hospital, Auckland, New Zealand
Abstract
Invariant NKT (iNKT) cells are involved in the pathogenesis of various infectious diseases. However, their role in hepatitis B
virus (HBV) infection is not fully understood, especially in human species. In this study, 35 chronic hepatitis B (CHB) patients,
25 inactive carriers (IC) and 36 healthy controls (HC) were enrolled and the proportions of circulating iNKT cells in fresh
isolated peripheral blood mononuclear cells (PBMC) were detected by flow cytometry. A longitudinal analysis was also
conducted in 19 CHB patients who received antiviral therapy with telbivudine. Thereafter, the immune functions of iNKT
cells were evaluated by cytokine secretion and a two-chamber technique. The median frequency of circulating iNKT cells in
CHB patients (0.13%) was lower than that in HC (0.24%, P = 0.01) and IC (0.19%, P = 0.02), and increased significantly during
antiviral therapy with telbivudine (P = 0.0176). The expressions of CC chemokine receptor 5 (CCR5) and CCR6 were
dramatically higher on
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