resting-state eeg source localization and functional connectivity in schizophrenia-like psychosis of epilepsy静息状态脑电源定位和功能连通性癫痫的精神分裂性精神病.pdfVIP

Resting-State EEG Source Localization and Functional Connectivity in Schizophrenia-Like Psychosis of Epilepsy 1 1 2,3 1 1 Leonides Canuet , Ryouhei Ishii *, Roberto D. Pascual-Marqui , Masao Iwase , Ryu Kurimoto , Yasunori 1 1 1 1 1 Aoki , Shunichiro Ikeda , Hidetoshi Takahashi , Takayuki Nakahachi , Masatoshi Takeda 1 Department of Psychiatry and Clinical Neuroscience, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan, 2 The KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Zurich, Switzerland, 3 Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan Abstract Background: It is unclear whether, like in schizophrenia, psychosis-related disruption in connectivity between certain regions, as an index of intrinsic functional disintegration, occurs in schizophrenia-like psychosis of epilepsy (SLPE). In this study, we sought to determine abnormal patterns of resting-state EEG oscillations and functional connectivity in patients with SLPE, compared with nonpsychotic epilepsy patients, and to assess correlations with psychopathological deficits. Methodology/Principal Findings: Resting EEG was recorded in 21 patients with focal epilepsy and SLPE and in 21 clinically- matched non-psychotic epilepsy controls. Source current density and functional connectivity were determined using eLORETA software. For connectivity analysis, a novel nonlinear connectivity measure called ‘‘lagged phase synchronization’’ was used. We found increased theta oscillations in regions involved in the default mode n