resting-state multi-spectrum functional connectivity networks for identification of mci patients静息状态的多光谱识别的功能连通性网络mci患者.pdfVIP

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resting-state multi-spectrum functional connectivity networks for identification of mci patients静息状态的多光谱识别的功能连通性网络mci患者.pdf

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resting-state multi-spectrum functional connectivity networks for identification of mci patients静息状态的多光谱识别的功能连通性网络mci患者

Resting-State Multi-Spectrum Functional Connectivity Networks for Identification of MCI Patients 1. 1. 2 2,3,4,5 4 Chong-Yaw Wee , Pew-Thian Yap , Kevin Denny , Jeffrey N. Browndyke , Guy G. Potter , 3,4,6 2 1 Kathleen A. Welsh-Bohmer , Lihong Wang , Dinggang Shen * 1 Image Display, Enhancement, and Analysis (IDEA) Laboratory, Biomedical Research Imaging Center (BRIC) and Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 2 Brain Imaging and Analysis Center (BIAC), Duke University Medical Center, Durham, North Carolina, United States of America, 3 Joseph and Kathleen Bryan Alzheimer’s Disease Research Center, Duke University Medical Center, Durham, North Carolina, United States of America, 4 Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America, 5 Duke Institute for Brain Sciences, Duke University, Durham, North Carolina, United States of America, 6 Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, North Carolina, United States of America Abstract In this paper, a high-dimensional pattern classification framework, based on functional associations between brain regions during resting-state, is proposed to accurately identify MCI individuals from subjects who experience normal aging. The proposed technique employs multi-spectrum networks to characterize the complex yet subtle blood oxygenation level dependent (BOLD) signal changes caused by pathological attacks. The utilization of multi-spectrum networks in ident