原创力文档risk factors and prognosis for neonatal sepsis in southeastern mexico analysis of a four-year historic cohort follow-up风险因素和预后进行新生儿败血症墨西哥东南部四年历史队列随访分析.pdfVIP
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risk factors and prognosis for neonatal sepsis in southeastern mexico analysis of a four-year historic cohort follow-up风险因素和预后进行新生儿败血症墨西哥东南部四年历史队列随访分析
Leal et al. BMC Pregnancy and Childbirth 2012, 12:48
/1471-2393/12/48
RESEARCH ARTICLE Open Access
Risk factors and prognosis for neonatal sepsis in
southeastern Mexico: analysis of a four-year
historic cohort follow-up
1* 2 3 4 5
Yelda A Leal , José Álvarez-Nemegyei , Juan R Velázquez , Ulises Rosado-Quiab , Nidia Diego-Rodríguez ,
Etna Paz-Baeza6 and Jorge Dávila-Velázquez
Abstract
Background: Neonatal sepsis is a worldwide public health issue in which, depending on the studied population,
marked variations concerning its risk and prognostic factors have been reported. The aim of this study was to
assess risk and prognostic factors for neonatal sepsis prevailing at a medical unit in southeastern Mexico. Thus, we
used a historic cohort design to assess the association between a series of neonates and their mothers, in addition
to hospital evolution features and the risk and prognosis of neonatal sepsis (defined by Pediatric Sepsis Consensus
[PSC] criteria) in 11,790 newborns consecutively admitted to a Neonatology Service in Mérida, Mexico, between
2004 and 2007.
Results: Sepsis was found in 514 of 11,790 (4.3 %) newborns; 387 of these cases were categorized as early-onset
(72 h) (75.3 %) and 127, as late-onset (72 h) (24.7 %). After logistic regression, risk factors for sepsis included the
following: low birth weight; prematurity; abnormal amniotic fluid; premature membrane rupture (PMR) at 24 h;
respiratory complications, and the requirement of assisted ventilation, O2 Inspiration fraction (IF) 60 %, or a
surgical procedure. Some of these factors were differentially associated with early- or late-onset neonatal sepsis. The
overall mortality rate of sepsis was 9.5 %. A marked differe
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