risk factors for antepartum stillbirth and the influence of maternal age in new south wales australia a population based study产前死胎的危险因素和母亲的年龄在澳大利亚新南威尔士州的影响基于人口的研究.pdfVIP
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risk factors for antepartum stillbirth and the influence of maternal age in new south wales australia a population based study产前死胎的危险因素和母亲的年龄在澳大利亚新南威尔士州的影响基于人口的研究
Gordon et al. BMC Pregnancy and Childbirth 2013, 13:12
/1471-2393/13/12
RESEARCH ARTICLE Open Access
Risk factors for antepartum stillbirth and the
influence of maternal age in New South Wales
Australia: A population based study
1,2* 2* 2 3,4 1,2
Adrienne Gordon , Camille Raynes-Greenow , Kevin McGeechan , Jonathan Morris and Heather Jeffery
Abstract
Background: Maternal age is a known risk factor for stillbirth and delayed childbearing is a societal norm in
developed country settings. The timing and reasons for age being a risk factor are less clear. This study aimed to
document the gestational specific risk of maternal age throughout pregnancy and whether the underlying causes
of stillbirth differ for older women.
Methods: Using linkage of state maternity and perinatal death data collections the authors assessed risk factors for
antepartum stillbirth in New South Wales Australia for births between 2002 – 2006 (n = 327,690) using a Cox
proportional hazards model. Gestational age specific risk was calculated for different maternal age groups. Deaths were
classified according to the Perinatal Mortality Classifications of the Perinatal Society of Australia and New Zealand.
Results: Maternal age was a significant independent risk factor for antepartum stillbirth (35 – 39 years HR 1.4 95%
CI 1.12 – 1.75; ≥ 40 years HR 2.41 95% CI 1.8 – 3.23). Other significant risk factors were smoking HR 1.82 (95% CI
1.56 –2.12) nulliparity HR 1.23 (95% CI 1.08 – 1.40), pre-existing hypertension HR 2.77 (95% CI 1.94 – 3.97) and
pre-existing diabetes HR 2.65 (95% CI 1.63 – 4.32). For women aged 40 or over the
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