risk factors for chronic cerebrospinal venous insufficiency (ccsvi) in a large cohort of volunteers慢性脑脊髓静脉功能不全的危险因素(ccsvi)群体的志愿者.pdfVIP

Risk Factors for Chronic Cerebrospinal Venous Insufficiency (CCSVI) in a Large Cohort of Volunteers 1 2 1 1 1 Kresimir Dolic , Bianca Weinstock-Guttman , Karen Marr , Vesela Valnarov , Ellen Carl , Jesper 1 1 1 2 1,3 Hagemeier , Christina Brooks , Colleen Kilanowski , David Hojnacki , Murali Ramanathan , Robert Zivadinov1,2* 1 Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo, New York, United States of America, 2 Department of Neurology, The Jacobs Neurological Institute, Kaleida Health, University at Buffalo, State University of New York, Buffalo, New York, United States of America, 3 Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, United States of America Abstract Background: The role of intra- and extra-cranial venous system impairment in the pathogenesis of various vascular, inflammatory and neurodegenerative neurological disorders, as well as in aging, has not been studied in detail. Nor have risk factors been determined for increased susceptibility of venous pathology in the intra-cranial and extra-cranial veins. The aim of this study was to investigate the association between presence of a newly proposed vascular condition called chronic cerebrospinal venous insufficiency (CCSVI) and environmental factors in a large volunteer control group without known central nervous system pathology. Methods and Findings: The data were collected in a prospective study from 252 subjects who were screened for medi