原创力文档risk factors for extended duration of acute diarrhea in young children风险因素在儿童急性腹泻持续时间延长.pdfVIP
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risk factors for extended duration of acute diarrhea in young children风险因素在儿童急性腹泻持续时间延长
Risk Factors for Extended Duration of Acute Diarrhea in
Young Children
1,2,3 4 ˚ 5,6 1,4 1,4
Tor A. Strand *, Pushpa R. Sharma , Hakon K. Gjessing , Manjeswori Ulak , Ram K. Chandyo ,
Ramesh K. Adhikari4, Halvor Sommerfelt1,3
1 Centre for International Health, University of Bergen, Bergen, Norway, 2 Medical Microbiology, Innlandet Hospital Trust, Lillehammer, Norway, 3 Division of Infectious
Disease Control, Norwegian Institute of Public Health, Oslo, Norway, 4 Department of Child Health, Tribhuvan University, Kathmandu, Nepal, 5 Department of
Epidemiology, Norwegian Institute of Public Health, Oslo, Norway, 6 Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
Abstract
Objective and Background: We sought to identify predictors of extended duration of diarrhea in young children, which
contributes substantially to the nearly 1 1/2 million annual diarrheal deaths globally.
Methods: We followed 6-35 month old Nepalese children enrolled in the placebo-arm of a randomized controlled trial with
391 episodes of acute diarrhea from the day they were diagnosed until cessation of the episode. Using multiple logistic
regression analysis, we identified independent risk factors for having diarrhea for more than 7 days after diagnosis.
Results: Infants had a 17 (95% CI 3.5, 83)-fold and toddlers (12 to 23 month olds) a 9.9 (95% CI 2.1, 47)-fold higher odds of
having such illness duration compared to the older children. Not being breastfed was associated with a 9.3 (95% CI 2.4,
35.7)-fold increase in the odds for this outcome. The odds also increased with increasing stool frequency. Furthermore,
having diarrhea in the monsoon season also increa
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