risk factors for invasive fungal disease in critically ill adult patients a systematic review侵袭性真菌病的危险因素在危重成人患者系统回顾.pdfVIP

Muskett et al. Critical Care 2011, 15:R287 /content/15/6/R287 RESEARCH Open Access Risk factors for invasive fungal disease in critically ill adult patients: a systematic review 1 1 1 1 1,2 1,3* Hannah Muskett , Jason Shahin , Gavin Eyres , Sheila Harvey , Kathy Rowan and David Harrison Abstract Introduction: Over 5,000 cases of invasive Candida species infections occur in the United Kingdom each year, and around 40% of these cases occur in critical care units. Invasive fungal disease (IFD) in critically ill patients is associated with increased morbidity and mortality at a cost to both the individual and the National Health Service. In this paper, we report the results of a systematic review performed to identify and summarise the important risk factors derived from published multivariable analyses, risk prediction models and clinical decision rules for IFD in critically ill adult patients to inform the primary data collection for the Fungal Infection Risk Evaluation Study. Methods: An internet search was performed to identify articles which investigated risk factors, risk prediction models or clinical decisions rules for IFD in critically ill adult patients. Eligible articles were identified in a staged process and were assessed by two investigators independently. The methodological quality of the reporting of the eligible articles was assessed using a set of questions addressing both general and statistical methodologies. Results: Thirteen articles met the inclusion criteria, of which eight articles examined risk factors, four developed a risk prediction model or clinical decision rule and one evaluated a clinical decision rule. Studies varied in terms of objectives