risk assessment to underpin food regulatory decisions an example of public health nutritional epidemiology风险评估食品监管决策支撑公共卫生营养流行病学的一个例子.pdfVIP
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risk assessment to underpin food regulatory decisions an example of public health nutritional epidemiology风险评估食品监管决策支撑公共卫生营养流行病学的一个例子
Nutrients 2011, 3, 164-185; doi:10.3390/nu30 10164
OPEN ACCESS
nutrients
ISSN 2072-6643
/journal/nutrients
Review
Risk Assessment to Underpin Food Regulatory Decisions: An
Example of Public Health Nutritional Epidemiology
Janis Baines, Judy Cunningham, Christel Leemhuis, Tracy Hambridge and Dorothy Mackerras *
Food Standards Australia New Zealand, PO Box 7186, Canberra BC, ACT 2610, Australia;
E-Mails: janis.baines@.au (J.B.); judy.cunningham@.au (J.C.);
christel.leemhuis@.au (C.L.); tracy.hambridge@.au (T.H.)
* Author to whom correspondence should be addressed;
E-Mail: dorothy.mackerras@.au; Tel.: +61-2-6271-2683; Fax: +61-2-6271-2278.
Received: 7 December 2010; in revised form: 9 January 2011 / Accepted: 18 January 2011 /
Published: 20 January 2011
Abstract: The approach used by food regulation agencies to examine the literature and
forecast the impact of possible food regulations has many similar features to the approach
used in nutritional epidemiological research. We outline the Risk Analysis Framework
described by FAO/WHO, in which there is formal progression from identification of the
nutrient or food chemical of interest, through to describing its effect on health and then
assessing whether there is a risk to the population based on dietary exposure estimates. We
then discuss some important considerations for the dietary modeling component of the
Framework, including several methodological issues that also exist in research nutritional
epidemiology. Finally, we give several case studies tha
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