salvianolic acid a protects the peripheral nerve function in diabetic rats through regulation of the ampk-pgc1α-sirt3 axissalvianolic酸糖尿病大鼠周围神经功能的保护通过调节ampk-pgc1α-sirt3轴.pdfVIP

Molecules 2012, 17, 11216-11228; doi:10.3390/molecules170911216 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Salvianolic Acid A Protects the Peripheral Nerve Function in Diabetic Rats through Regulation of the AMPK-PGC1α-Sirt3 Axis 1 1 1 2 1 3 Xiaoyan Yu , Li Zhang , Xiuying Yang , Huakang Huang , Zhonglin Huang , Lili Shi , Hengai Zhang 4 and Guanhua Du 1,* 1 Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China; E-Mails: yxypeony@163.com (X.Y.); zhangli@ (L.Z.); lucia@ (X.Y.); huangzl@ (Z.H.) 2 Department of Pharmacology, School of Basic Medical Science, Peking University HSC, 38 Xue Yuan Road, Beijing 100191, China; E-Mail: hua_kang_123@ 3 Tianjin Institute of Pharmaceutical Research, 308 Anshan Xidao, Nankai District, Tianjin 300193, China; E-Mail: lishi.shu@163.com 4 Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, China; E-Mail: ggi2005@126.com * Author to whom correspondence should be addressed; E-Mail: dugh@; Tel./Fax: +86-010-6316-5184. Received: 2 July 2012; in revised form: 6 September 2012 / Accepted: 6 September 2012 / Published: 20 September 2012 Abstract: Salvianolic acid A (SalA) is one of the main efficacious, water-soluble const