多囊卵巢综合征猕猴的生殖特性.pdfVIP

动 物 学 研 究 2012，Feb. 33(1): 37−42 CN 53-1040/Q ISSN 0254-5853 Zoological Research DOI ：10.3724/SP.J.1141.2012.01037 Reproductive traits of polycystic ovary syndrome in female rhesus monkeys 1,* 2 2 2 TANG Xiang-Hui , CAO Yue-Ling , YANG Ze-Xing , ZHAO Fu-Xian (1. Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China; 2. The Fourth Affiliated Hospital of Kunming Medical College, Kunming 650021, China) Abstract: The objective of this study was to set up a rhesus monkey model of polycystic ovary syndrome (PCOS), which is globally prevalent among reproductive-aged human women, and to understand the reproductive traits of PCOS female monkeys. Six adult female rhesus monkeys aged 6−10 a, were divided into a PCOS group and a control group. The PCOS group were given two cycles of subcutaneous injections of propionic acid testosterone (PAT), 3.5 mg/kg body weight, on day 1, day 3, and day 5 of the menstrual cycle, respectively, and then given muscle injections of human chorionic gonadotropin (HCG), 350 IU/kg body wtight, on day 7, day 9, and day 11, respectively. Results showed that high levels of serum LH and T [(5.35±0.17) IU/L and (7.58±0.14) ng/mL, respectively], and a high ratio value of LH/FSH (5.35/1.30=4.12) were observed in the PCOS group. No significant differences were found in serum FSH, E2, and P in the PCOS group compared with those of the control. Polycystic ovaries in the PCOS monkeys were recorded by live