Tefrs738499基因多态性与帕金森病不同亚型合并抑郁的相关性.PDF

Advances in Clinical Medicine 临床医学进展, 2017, 7(1), 23-29 Published Online March 2017 in Hans. /journal/acm /10.12677/acm.2017.71005 Association between Tef rs738499 Gene Polymorphism with Different Subtypes of Depression in Parkinson’s Disease Fan Huang, Xudong Pan, Na Li, Aijun Ma* The Neurology Department at Affiliated Hospital of Qingdao University, Qingdao Shandong th th th Received: Mar. 9 , 2017; accepted: Mar. 25 , 2017; published: Mar. 29 , 2017 Abstract Objective: To investigate the association between Tef rs738499 gene polymorphism and depres- sion in different subtypes of Parkinson’s disease in China’s northern Han nationality. Methods: A case-control study design was adopt in the 230 patients with Parkinson’s disease (PD group) and 250 healthy control subjects (control group). According to exercise symptoms and UPDRS score, PD group was divided into three types: Tremor type, postural disorder type and uncertainty type. PD patients were divided into depression group (PDD group, n = 116) and non-depression group (non-PDD, n = 114) according to HAMD score. Polymerase chain reaction combined with restric- tion endonuclease polymorphism (PCR-RFLP) were used to detect and sequence the distribution of Tef rs738499 allele and genotype. Results: (1) Compared with the control group, the allele of the T allele had no significant difference in the PD group (OR: 0.983 95% CI: 0.720 - 1.342 P = 0.913). There was no significant difference in wild type genotype that is TT genotype in the PD group (OR: 0.931 95% CI: 0.646 - 1.340 P = 0.699); (2) after PD patients were divided into PDD and n-PDD group, T allele between the two groups had stat