soft x-ray laser microscopy of lipid rafts towards gpcr-based drug discovery using time-resolved fret spectroscopy软x射线激光显微镜的脂质筏gpcr-based药物发现使用时间分辨光谱学.pdfVIP

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soft x-ray laser microscopy of lipid rafts towards gpcr-based drug discovery using time-resolved fret spectroscopy软x射线激光显微镜的脂质筏gpcr-based药物发现使用时间分辨光谱学.pdf

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soft x-ray laser microscopy of lipid rafts towards gpcr-based drug discovery using time-resolved fret spectroscopy软x射线激光显微镜的脂质筏gpcr-based药物发现使用时间分辨光谱学

Pharmaceuticals 2011, 4, 524-550; doi:10.3390/ph4030524 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Soft X-ray Laser Microscopy of Lipid Rafts towards GPCR- Based Drug Discovery Using Time-Resolved FRET Spectroscopy Motoyoshi Baba 1,2,*, Tohru Kozasa 3,4, Takao Hamakubo 3, Hiroto Kuroda 2, Kazuyuki Masuda 3, 2 3 Shin Yoneya and Tatsuhiko Kodama 1 Institute for Solid State Physics, University of Tokyo, Chiba 277, Japan 2 Department of Ophthalmology and Advanced Laser Medical Center, Faculty of Medicine, Saitama Medical University, Saitama 350, Japan; E-Mails: kuroda@saitama-med.ac.jp (H.K.); shin@saitama-med.ac.jp (S.Y.) 3 Laboratory for System Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153, Japan; E-Mails: kodama@ (T.K.); hamakubo@ (T.H.); masuda@ (K.M.) 4 Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA; E-Mail: tkozas@ (T.K.) * Author to whom correspondence should be addressed; E-Mail: baba@issp.u-tokyo.ac.jp or mbaba@saitama-med.ac.jp; Tel.: +81-4-7136-3367; Fax: +81-4-7136-3377 or Tel. / Fax +81-49-276-1224. Received: 17 December 2010; in revised form: 7 March 2011 / Accepted: 7 March 2011 / Published: 14 March 2011 Abstract: Many signaling molecules involved in G protein-mediated signal transduction, which are present in the lipid rafts and believed to be controlled spatially and temporally, influence the potency and efficacy of neurotransmitter receptors and tran