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Arthritis Research Therapy August 2005 Vol 7 No 4 Moser et al. Commentary Soluble RAGE: a hot new biomarker for the hot joint? Bernhard Moser, Barry I Hudson and Ann Marie Schmidt Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA Corresponding author: Ann Marie Schmidt, ams11@ Published: 3 June 2005 Arthritis Research Therapy 2005, 7:142-144 (DOI 10.1186/ar1764) This article is online at /content/7/4/142 © 2005 BioMed Central Ltd See related research by Pullerits et al., /content/7/4/R817 Abstract In this context, full interpretation of these findings will require The receptor for advanced glycation endproducts (RAGE) comprehensive answers to the questions such as the interacts with distinct ligand families linked to the inflammatory following: Do plasma sRAGE levels vary from day to day in a response. Studies in animal models suggest that RAGE is subject? Do they vary over the lifespan of the individual? upregulated in the inflamed joint and that blockade of the receptor, What were the levels of sRAGE in the RA subjects before the using a ligand decoy soluble form of RAGE (sRAGE), attenuates onset of disease manifestation? What other environmental or joint inflammation and expression of inflammatory and tissue- genetic factors might influence levels of sRAGE in the destructive mediators. In this issue of Arthritis Research Therapy, Rille Pulle