specific activation of estrogen receptor alpha and beta enhances male sexual behavior and neuroplasticity in male japanese quail具体激活雌激素受体α和β增强男性性行为和神经可塑性在雄性日本鹌鹑.pdfVIP

下载本文档

0
0
约9.37万字
约 10页
2017-09-12 发布于上海
举报
版权申诉

specific activation of estrogen receptor alpha and beta enhances male sexual behavior and neuroplasticity in male japanese quail具体激活雌激素受体α和β增强男性性行为和神经可塑性在雄性日本鹌鹑.pdf

1、本文档共10页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

specific activation of estrogen receptor alpha and beta enhances male sexual behavior and neuroplasticity in male japanese quail具体激活雌激素受体α和β增强男性性行为和神经可塑性在雄性日本鹌鹑

Specific Activation of Estrogen Receptor Alpha and Beta Enhances Male Sexual Behavior and Neuroplasticity in Male Japanese Quail 1 2 1 1 Aurore L. Seredynski , Gregory F. Ball , Jacques Balthazart , Thierry D. Charlier * ` ` 1 Research Group in Behavioral Neuroendocrinology, GIGA-Neurosciences, University of Liege, Liege, Belgium, 2 Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, United States of America Abstract Two subtypes of estrogen receptors (ER), ERa and ERb, have been identified in humans and numerous vertebrates, including the Japanese quail. We investigated in this species the specific role(s) of each receptor in the activation of male sexual behavior and the underlying estrogen-dependent neural plasticity. Castrated male Japanese quail received empty (CX) or testosterone-filled (T) implants or were daily injected with the ER general agonist diethylstilbestrol (DES), the ERa-specific agonist PPT, the ERb-specific agonist DPN or the vehicle, propylene glycol. Three days after receiving the first treatment, subjects were alternatively tested for appetitive (rhythmic cloacal sphincter movements, RCSM) and consummatory aspects (copulatory behavior) of male sexual behavior. 24 hours after the last behavioral testing, brains were collected and analyzed for aromatase expression and vasotocinergic innervation in the medial preoptic nucleus. The expression of RCSM was activated by T and to a lesser extent by DES and PPT but not by the ERbagonist DPN. In parallel, T fully restored the complete sequence of copulation, DES was partially active and the specific activation of ERa