specific selection of essential oil compounds for treatment of children’s infection diseases具体选择精油化合物用于治疗儿童感染疾病.pdfVIP

Pharmaceuticals 2004, 1, 1-30 Pharmaceuticals ISSN 1424-8247 /pharmaceuticals/ Review Specific Selection of Essential Oil Compounds for Treatment of Children’s Infection Diseases Alexander Pauli a,* and Heinz Schilcher b a ReviewScience, 90513 Zirndorf, Fürther Str. 13, Germany b Heinz Schilcher, 81737 München, Alfred Neumann Anger 17, Germany * Author to whom correspondence should be addressed; e-mail: a.pauli@ Received: 15 December 2003 / Accepted: 23 January 2004 / Published: 27 January 2004 Abstract: Preparations with essential oils and their dosages applied in the therapy of children’s infectious diseases are well documented. In contrast, information is only sparingly available about uses of isolated pure essential oil compounds for the treatment of such infections. To find out safe antimicrobials from essential oils, microbiological inhibitory data of children pathogens were combined with oral and dermal acute toxicity data to calculate oral and dermal therapeutical indices (TI). The superiority of antibiotic drugs became obvious following calculating oral TIs of antimicrobials from higher plants, which suggests that oral administrations of essential oil compounds are not suitable to cure severe infections. A few selected compounds from higher plants show moderate effectiveness against gram-positive bacteria, yeast and fungi, but not gram-negative bacteria. Topical application or inhalation of selected compounds for the treatment or additional treatment of mild infecti