spontaneous vesicles modulated by polymers自发通过聚合物囊泡调制.pdfVIP

Polymers 2011, 3, 1255-1267; doi:10.3390/polym3031255 OPEN ACCESS polymers ISSN 2073-4360 /journal/polymers Article Spontaneous Vesicles Modulated by Polymers M. Mercedes Velázquez 1,*, Margarita Valero 1 and Francisco Ortega 2 1 Departamento de Química Física, Universidad de Salamanca, E-37008 Salamanca, Spain; E-Mail: mvalero@usal.es 2 Departamento de Química Física I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain; E-Mail: fortega@quim.ucm.es * Author to whom correspondence should be addressed; E-Mail: mvsal@usal.es. Received: 7 June 2011; in revised form: 19 July 2011 / Accepted: 4 August 2011 / Published: 8 August 2011 Abstract: Vesicles are widely used in technological applications including cosmetic products, in microencapsulation for drug delivery, as anticancer agents and in the technology of adhesives, paints and inks. The vesicle size and the surface charge are very important properties from a technological point of view. Thus, the challenge in formulation is to find inexpensive stable vesicles with well-defined sizes and to modulate the surface charge of these aggregates. In this work we analyze the effect of different polymers on the structural properties of vesicles of the biodegradable surfactant sodium bis(2-ethyl-hexyl) sulfosuccinate, Aerosol OT. Using fluorescence, conductivity, electrophoretic mobility and dynamic light scattering measurements we study the effect of the polymer nature, molecular