stem cell transplantation for primary immunodeficiency disease experience of a singapore hospital原发性免疫缺陷疾病的干细胞移植新加坡医院的经验.pdfVIP

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stem cell transplantation for primary immunodeficiency disease experience of a singapore hospital原发性免疫缺陷疾病的干细胞移植新加坡医院的经验.pdf

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stem cell transplantation for primary immunodeficiency disease experience of a singapore hospital原发性免疫缺陷疾病的干细胞移植新加坡医院的经验

ORIGINAL ARTICLE Stem Cell Transplantation for Primary Immunodeﬁciency Disease: Experience of a Singapore Hospital Alison Joanne Lee, MBBS, MRCPCH, MMed (Paeds), 1 Jethro Wu, MBBS,2 Mariﬂ or Sarmiento Villegas, MD,1 Lynette Pei-Chi Shek, MBBS (Hons) MRCP (Paeds),1 Bee-Wah Lee, MBBS, MMed (Paeds), MD, FRCP (UK), FRCPCh (UK), FAAAAI,2 and Poh-Lin Tan, MBBS, MMed (Paeds)1 addition, early transplantation before the development of seri- Abstract: We retrospectively analyzed the outcomes of hematopoi- 1–6 ous infections has proven beneﬁcial. In our center, we have etic stem cell transplantation in 7 patients with primary immunode- performed SCT for the following PIDs: hyperimmunoglobulin M ﬁciency diseases treated at the National University Hospital, (HIgM) syndrome, severe combined immunodeﬁciency Singapore, over the period from December 1996 to January 2010. (SCID), leukocyte adhesion deﬁciency type 1 (LAD1), The primary immunodeﬁciency diseases managed were X-linked chronic granulomatous disease (CGD), and Wiskott–Aldrich hyperimmunoglobulin M syndrome (n ¼ 3), severe combined syndrome. This arti