stem cell transplantation for type 1 diabetes mellitus干细胞移植为1型糖尿病.pdfVIP

Diabetology Metabolic Syndrome BioMed Central Review Open Access Stem cell transplantation for type 1 diabetes mellitus Júlio C Voltarelli* and Carlos Eduardo Barra Couri Address: Department of Clinical Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Brazil Email: Júlio C Voltarelli* - jcvoltar@fmrp.usp.br; Carlos Eduardo Barra Couri - ce.couri@.br * Corresponding author Published: 16 September 2009 Received: 7 April 2009 Accepted: 16 September 2009 Diabetology Metabolic Syndrome 2009, 1:4 doi:10.1186/1758-5996-1-4 This article is available from: /content/1/1/4 © 2009 Voltarelli and Couri; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The use of stem cells to treat type 1 diabetes mellitus has been proposed for many years, both to downregulate the immune system and to provide β cell regeneration. Conclusion: High dose immunosuppression followed by autologous hematopoietic stem cell transplantation is able to induce complete remission (insulin independence) in most patients with early onset type 1 diabetes mellitus. Introduction ing importance in therapeutics. One of them is the Type 1 diabetes