stem cell-based neuroprotective and neurorestorative strategies干细胞神经保护和neurorestorative策略.pdfVIP

Int. J. Mol. Sci. 2010, 11, 2039-2055; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Stem Cell-Based Neuroprotective and Neurorestorative Strategies Chia-Wei Hung 1,4,†, Ying-Jay Liou 2,4,†, Shao-Wei Lu 5,†, Ling-Ming Tseng 3,4,†, Chung-Lan Kao 3,4, Shih-Jen Chen 3,4, Shih-Hwa Chiou 3,4,* and Charn-Jung Chang 5,* 1 Department of Neurology, Zhongxiao Branch, Taipei City Hospital/No.87, Tongde Rd., Nangang Dist., Taipei City 115, Taiwan 2 Department of Psychiatry, Taipei Veterans General Hospital/No.201, Sec. 2, Shih-Pai Road, Taipei 11217, Taiwan 3 Department of Medical Research and Education, Taipei Veterans General Hospital/No.201, Sec. 2, Shih-Pai Road, Taipei 11217, Taiwan 4 Institute of Clinical Medicine, National Yang-Ming University/No.155, Sec. 2, Linong St., Taipei 112, Taiwan 5 Department of Pharmacy, Tri-Service General Hospital National Defense Medical Center/No.325, Sec.2, Chenggong Rd., Neihu District, Taipei 114, Taiwan † These authors contributed equally to this work. * Authors to whom correspondence should be addressed: E-Mails: shchiou@.tw (S.-H.C.), michael0938@.tw (C.-J.C.); Tel.: +886-2-287-652-32 (S.-H.C.), +886-2-237-111-12 (C.-J.C.); Fax: +886-2-287-574-34 (S.-H.C.), +886-2-237-135-94 (C.-J.C.). Received: 23 March 2010; in revised form: 8 April 2010 / Accepted: 18 April 2010 / Published: 5 May 2010 Abstract: Stem cells, a special subset of cells derived from emb