原创力文档structural elucidation and bioactivity of biflavonoids from the stems of wikstroemia taiwanensis茎的结构说明和生物活性的biflavonoids wikstroemia taiwanensis.pdfVIP
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structural elucidation and bioactivity of biflavonoids from the stems of wikstroemia taiwanensis茎的结构说明和生物活性的biflavonoids wikstroemia taiwanensis
Int. J. Mol. Sci. 2012, 13, 1029-1038; doi:10.3390/ijms130 11029
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Structural Elucidation and Bioactivity of Biflavonoids from the
Stems of Wikstroemia taiwanensis
Li-Yin Chen 1,*, Ih-Sheng Chen 2 and Chien-Fang Peng 3
1 Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 71710, Taiwan
2 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708,
Taiwan; E-Mail: m635013@.tw
3 Department of Medical Laboratory Science and Biotechnology, College of Health Sciences,
Kaohsiung Medical University, Kaohsiung 80708, Taiwan; E-Mail: chfape@.tw
* Author to whom corresponding should be addressed; E-Mail: eijodesu@.tw;
Tel.: +886-6-266-4911 ext. 2209; Fax: +886-6-266-7318.
Received: 6 December 2011; in revised form: 1 January 2012 / Accepted: 10 January 2012 /
Published: 18 January 2012
Abstract: Three new biflavonoids, wikstaiwanones A–C (1–3), along with four known
compounds (4–7) were isolated from the stems of Wikstroemia taiwanensis
(Thymelaeaceae). Their structures were elucidated by spectroscopic analysis. Compounds 4
and 5 showed antitubercular activity against Mycobacterium tuberculosis with MIC values
of 15 μg/mL, respectively.
Keywords: Wikstroemia taiwanensis; Thymelaeaceae; stem; biflavonoid; antitubercular
activity
1. Introduction
Tuberculos
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