studying alternative splicing regulatory networks through partial correlation analysis通过偏相关分析研究可变剪接调控网络.pdfVIP

Volume 10, Issue 1, Article R3Chen and Zheng2009 Open Access Research Studying alternative splicing regulatory networks through partial correlation analysis * † Liang Chen and Sika Zheng Addresses: *Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA. †Howard Hughes Medical Institute, University of California, Los Angeles, MRL 6-619, Los Angeles, California 90095, USA. Correspondence: Liang Chen. Email: liang.chen@ Published: 9 January 2009 Received: 19 November 2008 Revised: 18 December 2008 Genome Biology 2009, 10:R3 (doi:10.1186/gb-2009-10-1-r3) Accepted: 9 January 2009 The electronic version of this article is the complete one and can be found online at /2009/10/1/R3 © 2009 Chen and Zheng; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Alternative splicing regulatory networkvides novel insights into the alternative splicing regulatory network./ppThe identification of links between exons and their regulators or targets and between co-spliced exons in human, mouse and rat pro- Abstract Background: Alternative pre-mRNA splicing is an important gene regulation mechanism for expanding proteomic diversity in higher eukaryotes. Each splicing regulator can potentially influe