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statins, bugs and prophylaxis intriguing possibilities他汀类药物,缺陷和预防有趣的可能性
Available online /content/10/5/168
Commentary
Statins, bugs and prophylaxis: intriguing possibilities
1 2 2
Marius Terblanche , Terry S Smith and Neill KJ Adhikari
1Department of Critical Care Medicine, St Thomas’ Hospital, Lambeth Palace Road, London SE1 7EH, UK
2Interdepartmental Division of Critical Care Medicine, University of Toronto, and Department of Critical Care Medicine, Sunnybrook Health Sciences
Centre, 2075 Bayview Avenue, Toronto, Canada, M4N 3M5
Corresponding author: Marius Terblanche, marius.terblanche@
Published: 27 October 2006 Critical Care 2006, 10:168 (doi:10.1186/cc5056)
This article is online at /content/10/5/168
© 2006 BioMed Central Ltd
Abstract Statins also inhibit the replication of cytomegalovirus (CMV).
Statin therapy may represent a potential prophylactic intervention Analysis of human umbilical-vein endothelial cells infected
in certain high-risk scenarios, for example in pandemic influenza with CMV and co-incubated with fluvastatin demonstrate
and in those undergoing aggressive medical treatments. Emerging significant reductions in CMV DNA [5]. Viral particle
data indicate a potential prophylactic role in these high-risk groups. concentrations are also lower. These effects are seen in
doses consistent with blood concentrations in vivo observed
during therapy in humans [6]. At
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