subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis软骨下骨显微结构的损害增加改造之前加剧实验性骨关节炎骨质疏松症.pdfVIP

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subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis软骨下骨显微结构的损害增加改造之前加剧实验性骨关节炎骨质疏松症.pdf

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subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis软骨下骨显微结构的损害增加改造之前加剧实验性骨关节炎骨质疏松症

Bellido et al. Arthritis Research Therapy 2010, 12:R152 /content/12/4/R152 RESEARCH ARTICLE Open Access Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis 1 1 1 1,2 3 3 Miriam Bellido , Laura Lugo , Jorge A Roman-Blas , Santos Castañeda , Jose R Caeiro , Sonia Dapia , Emilio Calvo4 1 1* , Raquel Largo , Gabriel Herrero-Beaumont Abstract Introduction: Osteoporosis (OP) increases cartilage damage in a combined rabbit model of OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at subchondral bone aggravates cartilage damage in this experimental model. Methods: OP was induced in 20 female rabbits, by ovariectomy and intramuscular injections of methylprednisolone hemisuccinate for four weeks. Ten healthy animals were used as controls. At week 7, OA was surgically induced in left knees of all rabbits. At 22 weeks, after sacrifice, microstructure parameters were assessed by micro-computed tomography, and osteoprotegerin (OPG), receptor activator of nuclear factor-B ligand (RANKL), alkaline phosphatase (ALP) and metalloproteinase 9 (MMP9) protein expressions were evaluated by Western Blot at subchondral bone. In addition, cartilage damage was estimated using the histopathological Mankin score. Mann-Whitney and Spearman statistical tests were performed as appropriate, using SPSS software v 11.0. Significant difference was established at P 0.05. Results: Subchondral bone area/tissue area, trabecular thickness and polar moment of inertia were diminished in OPOA knees compared with control or OA knees (P 0.05). A d