原创力文档subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution an intervention study亚临床反应健康自行车短暂暴露于空气污染与交通有关的干预研究.pdfVIP
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subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution an intervention study亚临床反应健康自行车短暂暴露于空气污染与交通有关的干预研究
Jacobs et al. Environmental Health 2010, 9:64
/content/9/1/64
RESEARCH Open Access
Subclinical responses in healthy cyclists briefly
exposed to traffic-related air pollution: an
intervention study
1 1,2* 3 3 4 5
Lotte Jacobs , Tim S Nawrot , Bas de Geus , Romain Meeusen , Bart Degraeuwe , Alfred Bernard ,
Muhammad Sughis1 1 4,6
, Benoit Nemery , Luc Int Panis
Abstract
Background: Numerous epidemiological studies have demonstrated adverse health effects of a sedentary life style,
on the one hand, and of acute and chronic exposure to traffic-related air pollution, on the other. Because physical
exercise augments the amount of inhaled pollutants, it is not clear whether cycling to work in a polluted urban
environment should be encouraged or not. To address this conundrum we investigated if a bicycle journey along
a busy commuting road would induce changes in biomarkers of pulmonary and systematic inflammation in a
group of healthy subjects.
Methods: 38 volunteers (mean age: 43 ± 8.6 years, 26% women) cycled for about 20 minutes in real traffic near a
major bypass road (road test; mean UFP exposure: 28,867 particles per cm3) in Antwerp and in a laboratory with
filtered air (clean room; mean UFP exposure: 496 particles per cm3). The exercise intensity (heart rate) and duration
of cycling were similar for each volunteer in both experiments. Exhaled nitric oxide (NO), plasma interleukin-6 (IL-6),
platelet function, Clara cell protein in serum and blood cell counts were measured before and 30 minutes after
exercise.
Results: Percentage of blood neutrophils increased significantly more (p = 0.004) after exercise in the road test
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