原创力文档subconjunctival dexamethasone implant for non-necrotizing scleritis为non-necrotizing结膜下地塞米松植入巩膜炎.pdfVIP
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subconjunctival dexamethasone implant for non-necrotizing scleritis为non-necrotizing结膜下地塞米松植入巩膜炎
Nascimento et al. Journal of Opthalmic Inflammation and Infection 2013, 3:7
/content/3/1/7
ORIGINAL RESEARCH Open Access
Subconjunctival dexamethasone implant
for non-necrotizing scleritis
1* 1 2 1 1
Heloisa Nascimento , Maíra França , Luciana Guadalupe García , Cristina Muccioli and Rubens Belfort Jr
Abstract
Background: The purpose of this study is to report the management of non-necrotizing anterior scleritis with a
single-dose subconjunctival 0.7 mg dexamethasone implant (OzurdexW, Allergan, Inc., CA, USA). Six patients with
clinical diagnosis of non-necrotizing anterior scleritis (diffuse, sectorial, and nodular) were submitted to
subconjunctival injection of dexamethasone implant. The injection was performed under topical anesthesia at the
slit lamp. All patients reported only mild discomfort related to the procedure. Five patients had subconjunctival
hemorrhage. Follow-up was performed 1, 7, 15, 30, and 45 days, and 2, 3, 4, 5, and 6 months after the procedure.
Visual acuity, intraocular pressure, anterior and posterior biomicroscopy, and fundus exams were performed in each
visit.
Results: In all patients, symptoms disappeared before day 7, and most of them were symptoms-free on day 2. The
implant was visible at least up to day 45. One recurrence was noted in the 6-month follow-up in a patient with
rheumatoid arthritis and non-necrotizing diffuse scleritis and was treated with oral steroids. No patient developed
ocular hypertension or any kind of complications during the follow-up period, except for subconjunctival
hemorrhage.
Conclusion: Dexamethasone implant was safely and effectively used as a local therapy for non-necrotizing scleritis.
Background
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