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Sensors 2010, 10, 11064-11071; doi:10.3390/s101211064 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article Surface-Enhanced Raman Scattering Sensor on an Optical Fiber Probe Fabricated with a Femtosecond Laser Xiaodong Ma 1,2, Haibin Huo 3, Wenhui Wang 1, Ye Tian 1, Nan Wu 1, Charles Guthy 1, Mengyan Shen 3 and Xingwei Wang 1,2,* 1 Department of Electrical and Computer Engineering, University of Massachusetts Lowell, One University Ave., Lowell, MA 01854, USA; E-Mails: xiaodong_ma@ (X.M.); wwhclp02@ (W.W.); ye_tian@ (Y.T.); nan_wu@ (N.W.); Charles_Guthy@ (C.G.) 2 Biomedical Engineering and Biotechnology Doctoral Program, University of Massachusetts Lowell, One University Ave., Lowell, MA 01854, USA 3 Department of Physics, University of Massachusetts Lowell, One University Ave., Lowell, MA 01854, USA; E-Mails: haibin_huo@ (H.H.); mengyan_shen@ (M.S.) * Author to whom correspondence should be addressed; E-Mail: xingwei_wang@; Tel: + 1-978-934-1981; Fax: + 1-978-934-3027. Received : 28 September 2010; in revisedform : 3 November 2010 / Accepted : 26 November 2010 / Published: 6 December 2010 Abstract: A novel fabrication method for surface-enhanced Raman scattering (SERS) sensors that used a fast femtosecond (fs) laser scanning process to etch uniform patterns and structures on the endface of a fused silica optical fiber, which is then coated with a thin layer of silver through thermal evaporation is presented. A high quality SERS signal was detected on the patterned surface using a Rhodamine 6G (Rh6G)