switching tnf antagonists in patients with chronic arthritis an observational study of 488 patients over a four-year period切换tnf拮抗剂在慢性关节炎患者488例历时四年的观察研究.pdfVIP

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switching tnf antagonists in patients with chronic arthritis an observational study of 488 patients over a four-year period切换tnf拮抗剂在慢性关节炎患者488例历时四年的观察研究.pdf

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switching tnf antagonists in patients with chronic arthritis an observational study of 488 patients over a four-year period切换tnf拮抗剂在慢性关节炎患者488例历时四年的观察研究

Available online /content/8/1/R29 Vol 8 No 1 Open Access Research article Switching TNF antagonists in patients with chronic arthritis: an observational study of 488 patients over a four-year period 1 2 3 Juan J Gomez-Reino , Loreto Carmona and the BIOBADASER Group 1Rheumatology Service and Department of Medicine, Hospital Clinico Universitario, Medical School, Universidad de Santiago de Compostela, Spain 2Unidad de Investigacion, Sociedad Española de Reumatologia, Madrid, Spain 3A list of participating investigators and centers appears in Acknowledgements Corresponding author: Juan J Gomez-Reino, juan.gomez-reino.carnota@sergas.es Received: 20 Jul 2005 Revisions requested: 7 Sep 2005 Revisions received: 7 Oct 2005 Accepted: 8 Dec 2005 Published: 6 Jan 2006 Arthritis Research Therapy 2006, 8:R29 (doi:10.1186/ar1881) This article is online at: /content/8/1/R29 © 2006 Gomez-Reino and Loreto Carmona; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The objective of this work is to analyze the survival of infliximab, of the TNF antagonist were 0.83 and 0.75, respectively. There etanercept and adalimumab in patients who have switched were 488 patients treated with more than one TNF antagonist. among tumor necrosis factor (TNF) antagonists for the In this situation, survival of the second TNF antagonist treat