synthesis and antitumor activities of derivatives of the marine mangrove fungal metabolite deoxybostrycin合成和衍生物抗肿瘤活性的海洋红树林真菌代谢物deoxybostrycin.pdfVIP

Mar. Drugs 2012, 10, 2715-2728; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin Hong Chen 1,†, Xun Zhu 2,3,†, Li-Li Zhong 1, Bing Yang 1, Jia Li 1, Jue-Heng Wu 2,3, Sheng-Ping Chen 2,3, Yong-Cheng Lin 1,3, Yuhua Long 4,* and Zhi-Gang She 1,3,* 1 School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China; E-Mails: chenwexpo@ (H.C.); zhonglili42@ (L.-L.Z.); yangbin_zs@163.com (B.Y.); nuekagami@163.com (J.L.); ceslyc@ (Y.-C.L.) 2 Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China; E-Mails: zhuxun8@ (X.Z.); wujh@ (J.-H.W.); chenshp@ (S.-P.C.) 3 Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China 4 School of Chemistry and Environment, South China Normal University, 348 West Outer Ring Road, Guangzhou 510006, China † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: longyh@ (Y.L.); cesshzhg@ (Z.-G.S.); Tel.: +86-20(Y.L.); Fax: +86-20(Y.L.); Tel.: +86-20-8411-3356 (Z.-G.S.); Fax: +86-20-8411-3356 (Z.-G.S.). Received: 30 October 2012; in revised form: 13 November 2012 / Accepted: 22 November 2012 / Published: 30 November 2012 Abstract: Deoxybostrycin (1) is an anthraquinone compound der