synthesis and biological activities on metal complexes of 2,5-diamino-1,3,4-thiadiazole derived from semicarbazide hydrochloride金属配合物的合成和生物活动2,5-diamino-1,3,4-thiadiazole来自盐酸氨基脲.pdfVIP

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2017-09-12 发布于上海
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synthesis and biological activities on metal complexes of 2,5-diamino-1,3,4-thiadiazole derived from semicarbazide hydrochloride金属配合物的合成和生物活动2,5-diamino-1,3,4-thiadiazole来自盐酸氨基脲.pdf

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synthesis and biological activities on metal complexes of 2,5-diamino-1,3,4-thiadiazole derived from semicarbazide hydrochloride金属配合物的合成和生物活动2,5-diamino-1,3,4-thiadiazole来自盐酸氨基脲

Molecules 2011, 16, 5861-5874; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Biological Activities on Metal Complexes of 2,5-Diamino-1,3,4-thiadiazole Derived from Semicarbazide Hydrochloride Joshua A. Obaleye 1, Johnson F. Adediji 2,* and Matthew A. Adebayo 2 1 Department of Chemistry, University of Ilorin, Ilorin, Kwara State, Nigeria; E-Mail: jobaleye@; Tel.: +2348033582048 2 Department of Chemical Sciences, Ajayi Crowther University, Oyo State, Nigeria * Author to whom correspondence should be addressed; E-Mail: dijijohnson@; Tel.: +2348035720485. Received: 30 April 2010; in revised form: 27 June 2011 / Accepted: 6 July 2011 / Published: 12 July 2011 Abstract: A bioactive ligand, 2,5-diamino-1,3,4-thiadiazole (L), derived from semicarbazide hydrochloride, and its metal complexes were prepared and characterized. The complexes were characterized using elemental, infra-red, ultraviolet/visible, magnetic moment, atomic absorption, thin layer chromatography and molar conductance measurements. The IR data revealed that the ligand (L) behaved as a tridentate neutral ligand. It coordinated to the metal ion via sulphur and nitrogen of the amines. The molar conductance data reveal that the chelates are non-electrolytes. From the Ultraviolet/Visible spectra and magnetic moment data, the complexes were found to have octahedral geometrical structure. In vivo evaluation