synthesis and biological evaluation of some novel schiff’s bases from 1,2,4-triazole合成和生物评价一些新奇的希夫氏基地从1、2,4-triazole.pdfVIP

Molecules 2007, 12, 1202-1209 molecules ISSN 1420-3049 © 2007 by MDPI /molecules Full Paper Synthesis and Biological Evaluation of Some Novel Schiff’s Bases from 1,2,4-Triazole Xiao-Xia Ye 1,2, Zhen-Fei Chen 1, An-Jiang Zhang 1 and Li-Xue Zhang 1,* 1 College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, P .R. China 2 Wenzhou Medical College, Wenzhou 325035, P. R. China; E-mail: wzmcyxx@ (Xiao-Xia Ye); E-mail: anjiangzhang@ (An-Jiang Zhang) * Author to whom correspondence should be addressed; E-mail: zhanglixuelz@; Tel: (+86)577 Fax: (+86)577 Received: 7 April 2007; in revised form: 3 June 200 7 / Accepted: 4 June 2007 / Published: 5 June 2007 Abstract: We have synthesized a number of novel Schiff’s bases from 4-amino-3-(D- glucoheptonic-hexitol-1-yl)-1H-1,2,4-triazole-5-thione. By attaching D-glucoheptonic- hexitol-1-yl residues to 1,2,4-triazole at the 3-position, the solubility of the title compounds has been improved greatly. All the products have been characterized by elemental analysis, IR, 1H-NMR, 13C-NMR and MS. The plant-growth regulating effects of the title compounds were examined. From the biological activity results, we found that most compounds showed weak to moderate activities. Keywords: Schiff’s bases, glucoheptonic acid residue, 4-amino-3-(D-glucoheptonic- hexitol-1-yl)-1H-1,2,4-triazole-5-thione, plant growth regulation Introduction Some Schiff’s bases bearing aryl gro